[The effect of solubilized methandrostenolone on muscle hypertrophy and on the blood biochemical indices in rats]

Eksp Klin Farmakol. May-Jun 1993;56(3):37-9.
[Article in Russian]

Abstract

The paper outlines a new mode of intravascular anabolic steroidal transport. The single intravenous administration of metandrostenolone aqueous solution to rats increases hypertrophy rate of MM. plantaris. It was shown that the action of a single dose (0.05 mg/kg) exceeded that of metandrostenolone oil solution in a dose of 5 mg/kg. The multiple reduction of doses of the anabolic drug and the high level of bioavailability were achieved. This effect was explained by the application of the specific transport agent.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Blood / drug effects*
  • Blood / metabolism
  • Dose-Response Relationship, Drug
  • Hypertrophy / blood
  • Hypertrophy / etiology
  • Male
  • Methandrostenolone / administration & dosage
  • Methandrostenolone / blood
  • Methandrostenolone / pharmacology*
  • Muscles / drug effects*
  • Muscles / pathology*
  • Rats
  • Rats, Wistar
  • Solubility
  • Time Factors

Substances

  • Methandrostenolone