Multicopy SUP35 gene induces de-novo appearance of psi-like factors in the yeast Saccharomyces cerevisiae

Curr Genet. 1993 Sep;24(3):268-70. doi: 10.1007/BF00351802.


Previously, we have shown that plasmid-mediated multiplication of Saccharomyces cerevisiae wild-type SUP35 gene leads to omnipotent suppression and is incompatible with psi-factor, which is an endogenous extrachromosomal suppressor. Here, we describe a frequent de-novo appearance of psi-like factors in mitotic progeny of yeast transformants containing multicopy SUP35 gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Fungal
  • Fungal Proteins / genetics*
  • Genes, Fungal*
  • Peptide Termination Factors
  • Plasmids
  • Prions*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins*
  • Suppression, Genetic
  • Transformation, Genetic


  • DNA, Fungal
  • Fungal Proteins
  • Peptide Termination Factors
  • Prions
  • SUP35 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins