Occupational allergic contact dermatitis caused by diethylenetriamine in carbonless copy paper

Contact Dermatitis. 1993 Sep;29(3):147-51. doi: 10.1111/j.1600-0536.1993.tb03513.x.


Carbonless copy paper, or 'no carbon required' (NCR) paper, has often been implicated as the cause of skin, respiratory, or general symptoms, but allergy has been verified in only a few cases. A 43-year-old machinist whose work involved the manufacture of NCR paper developed occupational dermatitis on the hands. On patch testing, both the NCR paper and 1 of the chemicals used to produce the microcapsules of the NCR paper, namely diethylenetriamine (DETA), provoked an allergic reaction. Analysis of the paper showed that it contained enough DETA to induce allergic contact dermatitis. People who handle NCR paper and develop symptoms of contact dermatitis should be patch tested with DETA.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Capsules
  • Dermatitis, Allergic Contact / etiology*
  • Dermatitis, Occupational / etiology*
  • Humans
  • Male
  • Microscopy, Electron, Scanning
  • Paper*
  • Patch Tests
  • Polyamines / adverse effects*


  • Capsules
  • Polyamines
  • diethylenetriamine