3' Non-Coding Region Sequences in Eukaryotic Messenger RNA

Nature. 1976 Sep 16;263(5574):211-4. doi: 10.1038/263211a0.

Abstract

The sequence A-A-U-A-A-A is present in six different purified messenger RNA molecules (specifically the alpha-and beta-globulin mRNAs of rabbit and human, the immunoglobulin light chain mRNA of mouse (MOPC 21) and the ovalbumin mRNA of chicken) about 20 residues away from the 3'-terminal poly (A) sequence. In addition, a large selection of the 3' non-coding regions of rabbit and human globulin mRNAs (both the alpha and beta globin mRNAs) are 85% homologous, demonstrating that this region is significantly conserved in evolution.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Base Sequence
  • Biological Evolution
  • Chickens
  • Globins / biosynthesis
  • Humans
  • Immunoglobulin Light Chains / biosynthesis
  • Mice
  • Myeloma Proteins / biosynthesis
  • Ovalbumin / biosynthesis
  • Poly A / analysis
  • RNA, Messenger / analysis*
  • Rabbits
  • Species Specificity

Substances

  • Immunoglobulin Light Chains
  • Myeloma Proteins
  • RNA, Messenger
  • Poly A
  • Globins
  • Ovalbumin

Associated data

  • GENBANK/J00079
  • GENBANK/J00093
  • GENBANK/J00094
  • GENBANK/J00096
  • GENBANK/J00153
  • GENBANK/J00154
  • GENBANK/J00155
  • GENBANK/J00156
  • GENBANK/J00158
  • GENBANK/J00159
  • GENBANK/J00160
  • GENBANK/J00161
  • GENBANK/J00162
  • GENBANK/J00163
  • GENBANK/J00164
  • GENBANK/J00165
  • GENBANK/J00166
  • GENBANK/J00167
  • GENBANK/J00168
  • GENBANK/J00169
  • GENBANK/J00170
  • GENBANK/J00171
  • GENBANK/J00172
  • GENBANK/J00173
  • GENBANK/J00174
  • GENBANK/J00175
  • GENBANK/J00177
  • GENBANK/J00178
  • GENBANK/J00179
  • GENBANK/K00418