Squamous-cell carcinoma arising in a non-irradiated child with recurrent respiratory papillomatosis

Eur J Pediatr. 1993 Sep;152(9):776-8. doi: 10.1007/BF01954001.


We describe a patient with recurrent respiratory papillomatosis (RRP) associated with human papilloma virus (HPV), who developed a fatal squamous cell carcinoma of the lung. At the age of 1 year he presented with hoarseness, dyspnoea and inspiratory stridor but the diagnosis of RRP was made only 1 year later. At the age of 4 years he was tracheostomized because of upper airway obstruction. In spite of multiple surgical excisions and topic treatment with 5-fluorouracil the papillomata extended to the lung parenchyma. At the age of 16 years he developed a squamous-cell carcinoma of the lung and died 4 months later. Transformation to pulmonary carcinoma is a rare complication in non-irradiated patients with lung papillomatosis. We found only 11 similar cases in the literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Carcinoma, Squamous Cell / pathology*
  • Cell Transformation, Neoplastic / pathology
  • Humans
  • Lung Neoplasms / pathology*
  • Male
  • Neoplasm Recurrence, Local / microbiology
  • Neoplasm Recurrence, Local / pathology*
  • Papilloma / microbiology
  • Papilloma / pathology*
  • Papillomaviridae
  • Papillomavirus Infections / pathology
  • Respiratory Tract Neoplasms / microbiology
  • Respiratory Tract Neoplasms / pathology*
  • Tumor Virus Infections / pathology