Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus

Eur J Pharmacol. 1993 Aug 3;239(1-3):265-6. doi: 10.1016/0014-2999(93)91009-c.


Long-term depression of synaptic transmission was induced following the prior induction of long-term potentiation in the CA1 region of rat hippocampal slices. We show that the induction of this form of synaptic depression can be prevented by (+)-alpha-methyl-4-carboxyphenylglycine, a selective antagonist of metabotropic glutamate receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzoates / pharmacology*
  • Electric Stimulation
  • Glycine / analogs & derivatives*
  • Glycine / pharmacology
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Rats
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors
  • Receptors, Metabotropic Glutamate / physiology*
  • Synaptic Transmission* / drug effects


  • Benzoates
  • Receptors, Metabotropic Glutamate
  • alpha-methyl-4-carboxyphenylglycine
  • Glycine