Free hydroxyl radicals are formed on reaction between the neutrophil-derived species superoxide anion and hypochlorous acid

FEBS Lett. 1993 Oct 25;333(1-2):151-3. doi: 10.1016/0014-5793(93)80394-a.


Superoxide anion reacts with hypochlorous acid to yield free hydroxyl radicals, as shown by the hydroxylation of benzoate. This reaction is analogous to the Haber-Weiss reaction but in the absence of metal ions is at least six orders of magnitude faster.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Gamma Rays
  • Hydroxyl Radical / metabolism*
  • Hypochlorous Acid / metabolism*
  • Models, Chemical
  • Neutrophils / metabolism*
  • Superoxides / metabolism*


  • Superoxides
  • Hydroxyl Radical
  • Hypochlorous Acid