Metabolic and behavioral covariates of high-density lipoprotein cholesterol and triglyceride concentrations in postmenopausal women

J Am Geriatr Soc. 1993 Dec;41(12):1289-94. doi: 10.1111/j.1532-5415.1993.tb06477.x.


Objective: To determine predictors of high-density lipoprotein cholesterol (HDL) and triglyceride (TG) concentrations in postmenopausal women.

Design: Cross-sectional study.

Setting: Clinical research facility.

Participants: One hundred twenty-seven healthy, relatively sedentary, postmenopausal women not on estrogen replacement, mean age 57 years.

Measurements: Alcohol intake, cigarette smoking, aerobic fitness (VO2max), body mass index (BMI), percent body fat, waist-hip ratio, lipids and lipoproteins, fasting plasma glucose (FPG), and insulin (FPI) concentrations.

Results: In univariate analyses, HDL was significantly (P < 0.05) inversely related to BMI, waist-hip ratio, smoking, FPG, and FPI, and directly related to VO2max and alcohol intake. Triglycerides were related directly to BMI, waist-hip ratio, percent body fat, FPG, and FPI, and inversely to VO2max. In stepwise multiple regressions, BMI, waist-hip ratio, alcohol, smoking, and FPG were significantly associated with HDL (R2 for the model = 0.43). Addition of TG to these models reduced relations of BMI and waist-hip ratio, but not the other variables, to insignificance. For triglycerides, waist-hip ratio, alcohol, smoking, FPG, and FPI were significant predictors (R2 = 0.33). VO2max and percent body fat did not contribute to any model.

Conclusions: Obesity, abdominal obesity, smoking, alcohol intake, and measures of carbohydrate metabolism predict HDL and triglyceride concentrations in postmenopausal women.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Drinking / physiopathology
  • Blood Glucose / analysis
  • Cholesterol, HDL / blood*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Insulin / blood
  • Middle Aged
  • Obesity / physiopathology
  • Oxygen Consumption
  • Postmenopause / blood
  • Postmenopause / metabolism
  • Postmenopause / physiology*
  • Regression Analysis
  • Smoking / physiopathology
  • Triglycerides / blood*


  • Blood Glucose
  • Cholesterol, HDL
  • Insulin
  • Triglycerides