Occurrence of capsular polysaccharide/adhesin among clinical isolates of coagulase-negative staphylococci

J Infect Dis. 1993 Nov;168(5):1211-8. doi: 10.1093/infdis/168.5.1211.

Abstract

Clinical isolates of coagulase-negative staphylococci were analyzed for elaboration of the capsular polysaccharide/adhesion (PS/A) and extracellular biofilm or slime. Of the 151 analyzed, 103 (68%) produced PS/A and 69 (46%) made extracellular slime; 87% of the slime-producing isolates made PS/A. Among isolates from all clinical infections examined except peritonitis, PS/A-positive isolates bound significantly (P < .001) more colony-forming units after 15 min to 1.5-cm segments of silicone-elastomer catheter than did PS/A-negative isolates. Slime-positive isolates were not more adherent than slime-negative isolates, because 42% of the PS/A-positive isolates were slime-negative. Thus, PS/A expression is common among clinical isolates of coagulase-negative staphylococci, accounting for most slime-positive and a proportion of slime-negative isolates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacterial Adhesion / physiology*
  • Bacterial Capsules / chemistry*
  • Catheters, Indwelling / adverse effects
  • Cell Adhesion Molecules / physiology*
  • Coagulase / deficiency
  • Humans
  • Polysaccharides, Bacterial / physiology*
  • Staphylococcal Infections / metabolism
  • Staphylococcus / chemistry
  • Staphylococcus / classification
  • Staphylococcus / enzymology
  • Staphylococcus / physiology*
  • Staphylococcus epidermidis / physiology

Substances

  • Cell Adhesion Molecules
  • Coagulase
  • Polysaccharides, Bacterial