Hypoprothrombinemia and severe hemorrhage associated with a lupus anticoagulant

J Pediatr. 1993 Dec;123(6):937-9. doi: 10.1016/s0022-3476(05)80390-7.


We recently encountered a previously healthy 3-year-old girl who had severe bleeding resulting from a severe deficiency of prothrombin. A lupus anticoagulant was identified by several different methods. The patient was successfully treated with glucocorticoids. This rare complication of a lupus anticoagulant should be considered in the differential diagnosis of a previously well child who suddenly has hemorrhage.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Female
  • Glucocorticoids / therapeutic use
  • Hemorrhage / complications*
  • Hemorrhage / drug therapy
  • Humans
  • Hypoprothrombinemias / blood
  • Hypoprothrombinemias / complications*
  • Hypoprothrombinemias / drug therapy
  • Lupus Coagulation Inhibitor / blood*


  • Glucocorticoids
  • Lupus Coagulation Inhibitor