Withdrawal of longterm antihyperuricemic therapy in tophaceous gout

J Rheumatol. 1993 Aug;20(8):1383-5.


Objective: To determine the effect of withdrawal of antihyperuricemic therapy on the recurrence of tophi and acute arthritis.

Methods: We performed a retrospective investigation of 21 patients with tophaceous gout who stopped therapy because they had no arthritis for years, and on examination tophi had disappeared.

Results: Nine patients (43%) had a recurrence of tophi after an average period of 39.6 months (range 4-107 months). Seventeen patients (81%) had attacks of acute arthritis, 6 patients within 6 months. During a mean period of drug discontinuation of 37.6 months no increase in serum creatinine or deterioration in joint function was observed.

Conclusion: Based on our data we conclude that intermittent usage of antihyperuricemic drugs will, after a variable period, result in the frequent recurrence of acute arthritis and tophi.

MeSH terms

  • Adult
  • Allopurinol / administration & dosage*
  • Allopurinol / therapeutic use
  • Drug Administration Schedule
  • Gout / drug therapy*
  • Gout / metabolism*
  • Humans
  • Middle Aged
  • Recurrence
  • Retrospective Studies
  • Time Factors
  • Uric Acid / blood*
  • Uric Acid / metabolism*
  • Uric Acid / urine
  • Uricosuric Agents / administration & dosage*
  • Uricosuric Agents / metabolism
  • Uricosuric Agents / therapeutic use


  • Uricosuric Agents
  • Uric Acid
  • Allopurinol