Effective Population Size, Genetic Diversity, and Coalescence Time in Subdivided Populations

J Mol Evol. 1993 Sep;37(3):240-4. doi: 10.1007/BF00175500.

Abstract

A formula for the effective population size for the finite island model of subdivided populations is derived. The formula indicates that the effective size can be substantially greater than the actual number of individuals in the entire population when the migration rate among subpopulations is small. It is shown that the mean nucleotide diversity, coalescence time, and heterozygosity for genes sampled from the entire population can be predicted fairly well from the theory for randomly mating populations if the effective population size for the finite island model is used.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Computer Simulation
  • Gene Frequency
  • Genetic Variation*
  • Heterozygote
  • Humans
  • Models, Genetic*
  • Population Density*
  • Sequence Homology, Nucleic Acid*
  • Time Factors