Molecular and biochemical features of poly (ADP-ribose) metabolism

Mol Cell Biochem. 1993 May 26;122(2):171-93. doi: 10.1007/BF01076101.

Abstract

In the past five years, poly(ADP-ribosyl)ation has developed greatly with the help of molecular biology and the improvement of biochemical techniques. In this article, we describe the physico-chemical properties of the enzymes responsible for the synthesis and degradation of poly(ADP-ribose), respectively poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase. We then discuss the possible roles of this polymer in DNA repair and replication as well as in cellular differentiation and transformation. Finally, we put forward various hypotheses in order to better define the function of this polymer found only in eucaryotes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Genetic Code
  • Humans
  • Molecular Sequence Data
  • Molecular Structure
  • Poly Adenosine Diphosphate Ribose / metabolism*
  • Poly Adenosine Diphosphate Ribose / physiology
  • Poly(ADP-ribose) Polymerases / genetics*
  • Poly(ADP-ribose) Polymerases / physiology
  • Protein Structure, Tertiary

Substances

  • Poly Adenosine Diphosphate Ribose
  • Poly(ADP-ribose) Polymerases