The subthalamic nucleus: a possible target for stereotaxic surgery in Parkinson's disease

Mov Disord. 1993 Oct;8(4):421-9. doi: 10.1002/mds.870080402.


Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basal Ganglia / anatomy & histology
  • Basal Ganglia / physiopathology
  • Basal Ganglia / surgery*
  • Dopamine / physiology
  • Female
  • Globus Pallidus / physiopathology
  • Haplorhini
  • Male
  • Neural Pathways
  • Parkinson Disease / physiopathology
  • Parkinson Disease / surgery*
  • Receptors, Glutamate / physiology
  • Stereotaxic Techniques*
  • Thalamic Nuclei / physiopathology
  • Thalamic Nuclei / surgery*
  • gamma-Aminobutyric Acid / physiology


  • Receptors, Glutamate
  • gamma-Aminobutyric Acid
  • Dopamine