Vigabatrin in the treatment of infantile spasms

Neuropediatrics. 1993 Aug;24(4):230-1. doi: 10.1055/s-2008-1071546.


The anti-epileptic effect of vigabatrin as a first choice therapy was investigated in 6 children suffering from infantile spasms (IS). All 6 children showed a reduction in seizure frequency. Three children became seizure-free within a period of 2 weeks. Because our results suggest "an all or nothing phenomenon", a period of 2 weeks may be sufficient to evaluate the efficacy of vigabatrin in untreated infants suffering from IS. We suggest to use vigabatrin as a first choice anti-epileptic drug in infants with IS.

MeSH terms

  • Aminocaproates / therapeutic use*
  • Anticonvulsants / therapeutic use*
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / physiopathology
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Electroencephalography / drug effects
  • Female
  • Humans
  • Infant
  • Male
  • Spasms, Infantile / drug therapy*
  • Spasms, Infantile / etiology
  • Spasms, Infantile / physiopathology
  • Vigabatrin


  • Aminocaproates
  • Anticonvulsants
  • Vigabatrin