Intracranial calcification in siblings with nephrogenic diabetes insipidus: CT and MRI

Neuroradiology. 1993;35(7):553-5. doi: 10.1007/BF00588723.


Computed tomography and magnetic resonance imaging (MRI) were used to examine three male siblings with nephrogenic diabetes insipidus (NDI). The two elder brothers had varying degrees of unusual intracranial calcification; the eldest also showed involvement of the cerebral white matter on MRI. The severity of intracranial calcification was related to the time before initiation of treatment and inversely to mental ability. Brain damage and mental retardation in NDI may be caused by a delay in initiating treatment; early detection and treatment are important to prevent brain damage.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Brain / pathology
  • Brain Diseases / diagnosis
  • Brain Diseases / genetics*
  • Calcinosis / diagnosis
  • Calcinosis / genetics*
  • Child, Preschool
  • Diabetes Insipidus / diagnosis
  • Diabetes Insipidus / genetics*
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Pedigree
  • Tomography, X-Ray Computed*
  • Water-Electrolyte Imbalance / diagnosis
  • Water-Electrolyte Imbalance / genetics