NMDA-evoked adenosine release from rat cortex does not require the intermediate formation of nitric oxide

Neurosci Lett. 1993 Aug 20;158(2):167-9. doi: 10.1016/0304-3940(93)90255-j.


Excitatory amino acids (EAAs) such as glutamate release the inhibitory neuromodulator adenosine from superfused rat cortical slices through the activation of both NMDA and non-NMDA EAA receptors. This study investigated the possibility that NMDA-evoked adenosine release may involve the intermediate formation of nitric oxide (NO). However, sodium nitroprusside did not evoke the release of adenosine, L-arginine did not augment and L-Nv-nitroarginine did not diminish NMDA-evoked adenosine release. It appears, therefore, that NMDA-evoked NO formation does not play a role in NMDA-evoked adenosine release in the cortex.

MeSH terms

  • Adenosine / metabolism*
  • Animals
  • Arginine / analogs & derivatives
  • Arginine / pharmacology
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism*
  • In Vitro Techniques
  • Male
  • N-Methylaspartate / pharmacology*
  • Nitric Oxide / biosynthesis*
  • Nitroarginine
  • Nitroprusside / pharmacology
  • Rats
  • Rats, Sprague-Dawley


  • Nitroprusside
  • Nitroarginine
  • Nitric Oxide
  • N-Methylaspartate
  • Arginine
  • Adenosine