Low-dose and high-dose mitomycin trabeculectomy as an initial surgery in primary open-angle glaucoma

Ophthalmology. 1993 Nov;100(11):1624-8. doi: 10.1016/s0161-6420(93)31426-0.


Purpose: The purpose of the study is to determine the optimum regimen of intraoperative administration of mitomycin as an adjunct to trabeculectomy.

Methods: Of 11 patients with primary open-angle glaucoma, 22 eyes that had not undergone any surgical intervention were included. In each patient, one eye was randomly allocated to a mitomycin 0.2-mg group and the fellow eye to a mitomycin 0.02-mg group. Mitomycin was applied for 5 minutes only once during trabeculectomy. The follow-up period was 6 to 17 months.

Results: Eleven (100%) eyes in the 0.2-mg group and 7 (63.6%) in the 0.02-mg group achieved successful control of intraocular pressure with or without topical antiglaucoma medication. Transient hypotony maculopathy (18%) and cataract progression (18%) were noted in the 0.2-mg group exclusively. The incidence of other complications was similar between the two groups.

Conclusion: These data suggest that the most appropriate dose of mitomycin for primary surgery seems to be in between the two doses tested in the current study.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Glaucoma, Open-Angle / drug therapy*
  • Glaucoma, Open-Angle / surgery*
  • Humans
  • Intraocular Pressure
  • Intraoperative Care
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage*
  • Mitomycin / therapeutic use
  • Postoperative Complications
  • Prognosis
  • Prospective Studies
  • Trabeculectomy*


  • Mitomycin