Wide variation in patient response to midazolam sedation for outpatient oral surgery

Oral Surg Oral Med Oral Pathol. 1993 Oct;76(4):408-11. doi: 10.1016/0030-4220(93)90004-n.


Intravenous midazolam in doses of between 0.07 mg/kg and 0.1 mg/kg has been recommended for sedation in dentistry and some medical procedures and investigations. This study examined the variable sensitivity of patients to midazolam. One hundred and thirty-four fit but anxious patients between the ages of 16 and 63 years received midazolam intravenously for sedation for minor oral surgery. Doses required ranged from 0.04 to 0.40 mg/kg. Nineteen patients required doses less than 0.07 mg/kg; 59 patients required doses greater than 0.1 mg/kg. The mean dose per kilogram required for males was significantly less than for females. The wide variation in sensitivity to midazolam is confirmed.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Ambulatory Surgical Procedures / methods
  • Anesthesia, Dental / methods*
  • Apicoectomy
  • Body Weight
  • Conscious Sedation / methods*
  • Dental Anxiety / prevention & control*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Midazolam / administration & dosage*
  • Middle Aged
  • Tooth Extraction


  • Midazolam