Reduction of cortical volume in schizophrenia on magnetic resonance imaging

Psychol Med. 1993 Aug;23(3):591-604. doi: 10.1017/s003329170002537x.


The MRI scans of 48 schizophrenic patients, fulfilling RDC criteria, were compared to those of 34 healthy controls matched for age, ethnicity and parental social class. The volume of the frontal and anterior parietal lobes was significantly reduced in the schizophrenic group as a result of a selective decrease in cortical volume, with a corresponding increase in the volume of sulcal fluid. Reduction in the volume of the temporal grey matter was more marked on the right, but was not in excess of the loss of volume observed in other areas of the cortex. MRI abnormalities correlated poorly with clinical parameters, although both unemployment and poor pre-morbid adjustment predicted reduced cerebral volume and increased sulcal volume. These results question whether the medial temporal lobes are the only site of structural pathology in schizophrenia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Brain / abnormalities
  • Brain / diagnostic imaging*
  • Employment
  • Female
  • Functional Laterality
  • Hippocampus / abnormalities*
  • Humans
  • Intelligence
  • Intelligence Tests
  • Magnetic Resonance Imaging
  • Male
  • Psychiatric Status Rating Scales
  • Radiography
  • Schizophrenia / cerebrospinal fluid
  • Schizophrenia / diagnosis
  • Schizophrenia / etiology*
  • Temporal Lobe / abnormalities