[Value of standardized Ginkgo biloba extract (EGb 761) in the management of congestive symptoms of premenstrual syndrome]

Rev Fr Gynecol Obstet. Jul-Sep 1993;88(7-9):447-57.
[Article in French]


The efficacy of standardized Ginkgo biloba extract (EGb 761) in treating congestive symptoms of premenstrual syndrome (PMS) was evaluated in a controlled multicentric double blind study versus placebo. The population studied was a group of 165 women aged between 18 to 45, in genital activity period, suffering since 3 cycles from congestive premenstrual troubles during at least 7 days per cycle. The characteristics of patients and PMS were the same in both groups (EGb 761 and placebo). The observation of one menstrual cycle confirmed the diagnosis of PMS. Then, during the 2 following cycles, each patient received either EGb 761 or placebo from the 16th day of the first cycle till the 5th day of the next cycle. A double evaluation of the symptoms was realized by the patient using a daily rating scale (auto-evaluation), by the practitioner during visits at the premenstrual phase before and after the two cycles treatment. From 165 patients included, 143 observations were available. With a good acceptability, EGb 761 was effective against the congestive symptoms of PMS, particularly breast symptoms with a statistical significance between EGb 761 and placebo. Neuropsychological symptoms were also improved. EGb 761 is an alternative of interest to therapeutics already used in treating PMS or can be associated without any inconvenience.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Double-Blind Method
  • Edema / diagnosis
  • Edema / drug therapy*
  • Edema / physiopathology
  • Edema / psychology
  • Female
  • Ginkgo biloba
  • Humans
  • Medical Records
  • Middle Aged
  • Plant Extracts / therapeutic use*
  • Premenstrual Syndrome / diagnosis
  • Premenstrual Syndrome / drug therapy*
  • Premenstrual Syndrome / physiopathology
  • Premenstrual Syndrome / psychology


  • Plant Extracts
  • Ginkgo biloba extract