Intracranial plasma cell granuloma presenting as an optic neuropathy

Surv Ophthalmol. 1993 Jul-Aug;38(1):70-4. doi: 10.1016/0039-6257(93)90056-d.


A 40-year-old man presented with a left optic neuropathy. Magnetic resonance imaging demonstrated a contrast-enhancing mass along the course of the left trigeminal nerve and in the region of the left cavernous sinus with suprasellar extension. Preoperatively, he had a serum polyclonal gammopathy. Pathologic diagnosis was an intracranial plasma cell granuloma. The patient responded to high-dose steroids with resolution of his optic neuropathy, marked decrease in the size of the mass, and resolution of the serum polyclonal gammopathy. Intracranial plasma cell granuloma is a rare lesion; only 11 cases have been described in the literature. Almost half of the patients presented with vision loss as their chief complaint.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Diseases / diagnosis*
  • Brain Diseases / drug therapy
  • Brain Diseases / surgery
  • Diagnosis, Differential
  • Granuloma, Plasma Cell / diagnosis*
  • Granuloma, Plasma Cell / drug therapy
  • Granuloma, Plasma Cell / surgery
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Optic Nerve Diseases / diagnosis*
  • Optic Nerve Diseases / drug therapy
  • Prednisone / therapeutic use
  • Trigeminal Nerve / pathology


  • Prednisone