Requiem for distributive segregation: achiasmate segregation in Drosophila females

Trends Genet. 1993 Sep;9(9):310-7. doi: 10.1016/0168-9525(93)90249-h.


The segregation of achiasmate chromosome pairs at meiosis I is not brought about by a single 'distributive system' as previously thought, but rather by two separate mechanisms. One system uses the pairing of proximal heterochromatic sequences to mediate the segregation of achiasmate homologs-an observation that, at long last, defines a function for heterochromatin. The other system facilitates the segregation of heterologous chromosomes, by an as yet undiscovered mechanism.

Publication types

  • Review

MeSH terms

  • Animals
  • Centromere / physiology
  • Chromosomes / physiology
  • Crossing Over, Genetic
  • Drosophila Proteins*
  • Drosophila melanogaster / genetics*
  • Female
  • Heterochromatin / physiology
  • Heterochromatin / ultrastructure
  • Kinesins
  • Meiosis*
  • Microtubule Proteins / physiology
  • Models, Genetic*
  • Nondisjunction, Genetic
  • Sequence Homology, Nucleic Acid


  • Drosophila Proteins
  • Heterochromatin
  • Microtubule Proteins
  • Nod protein, Drosophila
  • Kinesins