The effect of intrapartum epidural analgesia on nulliparous labor: a randomized, controlled, prospective trial

Am J Obstet Gynecol. 1993 Oct;169(4):851-8. doi: 10.1016/0002-9378(93)90015-b.

Abstract

Objective: Our purpose was to determine the effect of epidural analgesia on nulliparous labor and delivery.

Study design: Normal term nulliparous women in early spontaneous labor were randomized to receive either narcotic or epidural analgesia.

Results: When compared with the group receiving narcotic analgesia (n = 45), the group receiving epidural analgesia (n = 48) had a significant prolongation in the first and second stages of labor, an increased requirement for oxytocin augmentation, and a significant slowing in the rate of cervical dilatation. Epidural analgesia was associated with a significant increase in malposition (4.4% vs 18.8%, p < 0.05). Cesarean delivery occurred more frequently in the epidural group (2.2% vs 25%, p < 0.05), primarily related to an increase in cesarean section for dystocia (2.2% vs 16.7%, p < 0.05).

Conclusions: In a randomized, controlled, prospective trial epidural analgesia resulted in a significant prolongation in the first and second stages of labor and a significant increase in the frequency of cesarean delivery, primarily related to dystocia.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analgesia, Epidural / adverse effects*
  • Analgesia, Obstetrical / adverse effects*
  • Analysis of Variance
  • Apgar Score
  • Bupivacaine / adverse effects
  • Bupivacaine / therapeutic use
  • Cesarean Section / statistics & numerical data
  • Delivery, Obstetric
  • Female
  • Fetal Blood / chemistry
  • Fetal Blood / drug effects
  • Humans
  • Injections, Intravenous
  • Labor Presentation
  • Labor, Obstetric / drug effects*
  • Meperidine / administration & dosage
  • Meperidine / therapeutic use
  • Oxytocin / therapeutic use
  • Pain Measurement
  • Parity
  • Pregnancy
  • Promethazine / administration & dosage
  • Promethazine / therapeutic use
  • Prospective Studies
  • Time Factors

Substances

  • Oxytocin
  • Meperidine
  • Promethazine
  • Bupivacaine