PKC translocation in rat brain cortex is promoted in vivo and in vitro by alpha-glycerylphosphorylcholine, a cognition-enhancing drug

Ann N Y Acad Sci. 1993 Sep 24;695:307-10. doi: 10.1111/j.1749-6632.1993.tb23072.x.

Abstract

Protein kinase C (PKC) activity was measured in soluble and particulate fractions of rat individual brain areas after treatment with alpha-glycerylphosphorylcholine (GPC), a cognition-enhancing drug which promotes acetylcholine synthesis and release. The drug induced both in vivo and in vitro PKC translocation. In vivo, an increase of particulate PKC activity was observed 1 hour following the acute oral administration of a behaviorally active dose (600 mg/kg); the effect was transient. In vitro, GPC promoted PKC translocation in cortical slices at concentrations as low as 50 nM; the concentration-response curve was bell shaped. The increased PKC activity may be related to the cortical effects of GPC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine / pharmacology
  • Animals
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / enzymology*
  • Cognition / drug effects*
  • Glycerylphosphorylcholine / pharmacology*
  • In Vitro Techniques
  • Male
  • Protein Kinase C / metabolism*
  • Rats
  • Rats, Wistar

Substances

  • Glycerylphosphorylcholine
  • Amphetamine
  • Protein Kinase C