Maternal and neonatal outcome associated with prolonged premature rupture of membranes below 26 weeks' gestation

Am J Perinatol. 1993 Sep;10(5):369-73. doi: 10.1055/s-2007-994764.


The outcomes of 41 patients with prolonged, premature rupture of membranes in the midtrimester (19.5 to 26 weeks) managed conservatively were retrospectively analyzed. The maternal obstetric history was notable for a high incidence of second trimester bleeding and a prior history of preterm delivery. The mean duration of ruptured membranes before delivery was 10.6 days and was unrelated to gestational age. Delivery occurred within 2 weeks in 75% of the cases. The major indication for delivery was chorioamnionitis in 71% of patients. The only major maternal morbidity was chorioamnionitis. The overall perinatal survival was 47%, but in infants exceeding 24 weeks' gestation or 500 gm weight, the survival increased to 75%. No significant limb abnormalities, facial anomalies, growth retardation, or pulmonary hypoplasia occurred in the study population. Long-term follow-up demonstrated that 28% of infants exhibited major neurologic or developmental deficits.

MeSH terms

  • Adolescent
  • Adult
  • Cesarean Section / statistics & numerical data
  • Chorioamnionitis / epidemiology
  • Chorioamnionitis / etiology
  • Female
  • Fetal Membranes, Premature Rupture / complications*
  • Follow-Up Studies
  • Humans
  • Incidence
  • Infant Mortality
  • Infant, Newborn
  • Morbidity
  • Obstetric Labor, Premature / epidemiology
  • Obstetric Labor, Premature / etiology
  • Pregnancy
  • Pregnancy Outcome*
  • Pregnancy Trimester, Second
  • Retrospective Studies
  • Risk Factors