Cytokines as mediators of organ graft rejection and tolerance

Curr Opin Immunol. 1993 Oct;5(5):788-93. doi: 10.1016/0952-7915(93)90138-i.


The analysis of cytokines following organ transplantation continues to flourish as a major area of investigation for transplant biologists. Over the past year many papers have reported the use of both molecular and antibody-based tools to dissect the expression of cytokines during graft rejection in both experimental and clinical transplantation. Further, how the expression of cytokines is altered during the induction of tolerance has been investigated by several groups.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytokines / biosynthesis
  • Cytokines / immunology*
  • Graft Rejection / immunology*
  • Humans
  • Immune Tolerance*
  • Interleukin-6 / biosynthesis
  • Interleukin-6 / immunology
  • Organ Transplantation*
  • Polymerase Chain Reaction
  • Tumor Necrosis Factor-alpha / biosynthesis
  • Tumor Necrosis Factor-alpha / immunology


  • Cytokines
  • Interleukin-6
  • Tumor Necrosis Factor-alpha