Evolution and role of Pax genes

Curr Opin Genet Dev. 1993 Aug;3(4):595-605. doi: 10.1016/0959-437x(93)90095-7.


Pax genes encode a class of highly conserved transcription factors containing a paired-domain. These factors play important roles in Drosophila and vertebrate development, for example, in segmentation and neurogenesis. Their developmental roles are assessed in terms of their participation in conserved gene networks and mechanisms that establish positional information.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Central Nervous System / embryology
  • DNA-Binding Proteins / genetics
  • Drosophila / embryology
  • Drosophila / genetics*


  • DNA-Binding Proteins