The community effect, dorsalization and mesoderm induction

Curr Opin Genet Dev. 1993 Aug;3(4):662-7. doi: 10.1016/0959-437x(93)90104-w.


The community effect is an interaction among muscle progenitor cells of amphibian gastrula, and is necessary for the initiation of muscle-specific gene expression. Dorsalization provides a signal that can convert ventral mesoderm cells to a muscle fate. Neither process involves mesoderm-inducing molecules. We suggest that the developmental significance of the community effect is to generate homogeneous but clearly demarcated groups of cells from progenitor cells arranged in a continuous gradient of developmental potential.

Publication types

  • Review

MeSH terms

  • Animals
  • Embryonic Induction*
  • Gastrula
  • Mesoderm*
  • Muscles / cytology
  • Muscles / embryology*