The interaction between central cholinergic and peripheral beta-adrenergic systems on radial maze performance in rats

Brain Res. 1993 Sep 17;622(1-2):353-6. doi: 10.1016/0006-8993(93)90844-d.

Abstract

The interaction between cholinergic and beta-adrenergic systems on radial arm maze performance was investigated. Scopolamine significantly disrupted radial maze performance. Although neither propranolol (a centrally and peripherally acting beta-antagonist), nor atenolol (a peripherally acting beta 1-antagonist) affected the maze performance, both antagonists significantly augmented the scopolamine disruption. These results suggest the importance of the interaction between central cholinergic and peripheral beta-adrenergic systems on radial maze performance.

MeSH terms

  • Acetylcholine / physiology*
  • Animals
  • Atenolol / pharmacology
  • Male
  • Propranolol / pharmacology
  • Psychomotor Performance / drug effects*
  • Rats
  • Rats, Wistar
  • Scopolamine / pharmacology
  • Spatial Behavior / drug effects
  • Spatial Behavior / physiology*
  • Sympathetic Nervous System / physiology*

Substances

  • Atenolol
  • Propranolol
  • Scopolamine
  • Acetylcholine