Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats

Eur J Pharmacol. 1993 Sep 14;241(2-3):271-3. doi: 10.1016/0014-2999(93)90214-3.


The hemodynamic effects of human adrenomedullin were investigated in anesthetized Wistar rats. Intravenous administration of adrenomedullin (1.0 nmol/kg) caused a rapid and marked reduction in mean blood pressure associated with a decrease in total peripheral resistance. This reduction in mean blood pressure was closely correlated with the decrease in total peripheral resistance. These findings indicate that human adrenomedullin is a potent vasodilator and may have some role in the regulation of blood pressure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenomedullin
  • Animals
  • Antihypertensive Agents / pharmacology*
  • Blood Pressure / drug effects
  • Cardiac Output / drug effects
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Humans
  • Male
  • Peptides / pharmacology*
  • Rats
  • Rats, Wistar
  • Stroke Volume / drug effects
  • Vascular Resistance / drug effects


  • Antihypertensive Agents
  • Peptides
  • Adrenomedullin