The human prohibitin (PHB) gene family and its somatic mutations in human tumors

Genomics. 1993 Sep;17(3):762-4. doi: 10.1006/geno.1993.1402.


Five cosmid clones, isolated by procedures to screen genomic libraries for homologous variants of the human prohibitin gene (PHB), were analyzed to determine their genomic structures. Four of these (PHBP1-4) were found to be processed pseudogenes, each located on a different chromosome from their counterparts on chromosome 17q21. The DNA sequence of one clone (PHBP1, on chromosome 6q25) shared a 91.3% identity at the nucleotide level with the cDNA of functional prohibitin. A large number of human tumors of the breast, ovary, liver, and lung were examined for somatic mutations in the PHB gene. Although mutations were observed in a few sporadic breast cancers, none were identified in any of the other cancers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Breast Neoplasms / genetics
  • Chromosomes, Human, Pair 17
  • Chromosomes, Human, Pair 6
  • Cloning, Molecular
  • Cosmids
  • DNA, Complementary / genetics
  • Female
  • Genes, Tumor Suppressor*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Liver Neoplasms / genetics
  • Lung Neoplasms / genetics
  • Molecular Sequence Data
  • Multigene Family*
  • Mutation
  • Neoplasms / genetics*
  • Ovarian Neoplasms / genetics
  • Proteins / genetics*
  • Pseudogenes
  • Repressor Proteins*


  • DNA, Complementary
  • Proteins
  • Repressor Proteins
  • prohibitin

Associated data

  • GENBANK/L14272
  • GENBANK/L14273
  • GENBANK/L14274
  • GENBANK/L14284
  • GENBANK/L14485