Brain-derived Neurotrophic Factor Expression After Long-Term Potentiation

Neurosci Lett. 1993 Oct 1;160(2):232-6. doi: 10.1016/0304-3940(93)90420-p.


Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Brain-Derived Neurotrophic Factor
  • Dizocilpine Maleate / pharmacology
  • Evoked Potentials / drug effects
  • Gene Expression / drug effects
  • In Situ Hybridization
  • Long-Term Potentiation* / drug effects
  • Male
  • Nerve Growth Factors / biosynthesis*
  • Nerve Tissue Proteins / biosynthesis*
  • RNA, Messenger / biosynthesis*
  • Rats
  • Rats, Sprague-Dawley


  • Brain-Derived Neurotrophic Factor
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • RNA, Messenger
  • Dizocilpine Maleate