Abstract
The E2F family of transcription factors functions in the control of the mammalian cell cycle. Here it is shown that two family members, E2F-1 and DP-1, form specific heterodimers in vivo, a process that enhances DNA binding, transactivation, and the binding of the retinoblastoma gene product. These results suggest that heterodimerization regulates E2F function and contributes to cell cycle control.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Biopolymers
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Carrier Proteins*
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Cell Cycle Proteins*
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DNA-Binding Proteins / metabolism*
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E2F Transcription Factors
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E2F1 Transcription Factor
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Hemagglutinin Glycoproteins, Influenza Virus
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Hemagglutinins, Viral
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Molecular Sequence Data
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Protein Binding
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Recombinant Proteins / metabolism
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Retinoblastoma Protein / metabolism*
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Retinoblastoma-Binding Protein 1
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Transcription Factors / metabolism*
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Transcriptional Activation / physiology
Substances
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Biopolymers
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Carrier Proteins
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Cell Cycle Proteins
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DNA-Binding Proteins
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E2F Transcription Factors
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E2F1 Transcription Factor
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Hemagglutinin Glycoproteins, Influenza Virus
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Hemagglutinins, Viral
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Recombinant Proteins
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Retinoblastoma Protein
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Retinoblastoma-Binding Protein 1
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Transcription Factors