Molecular basis of muscarinic acetylcholine receptor function

Trends Pharmacol Sci. 1993 Aug;14(8):308-13. doi: 10.1016/0165-6147(93)90049-p.


Muscarinic acetylcholine receptors play important roles in numerous physiological functions including higher cognitive processes such as memory and learning. Consistent with the well-documented pharmacological heterogeneity of muscarinic receptors, molecular cloning studies have revealed the existence of five distinct muscarinic receptor proteins (M1-M5). Structure-function relationship studies of the cloned receptors have been greatly aided by the high degree of structural homology that muscarinic receptors share with other G protein-coupled receptors. In this review, Jürgen Wess discusses recent mutagenesis studies that have considerably advanced our knowledge of the molecular details underlying muscarinic receptor function.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • GTP-Binding Proteins / metabolism
  • Molecular Sequence Data
  • Protein Binding
  • Protein Conformation
  • Receptors, Muscarinic / chemistry*
  • Receptors, Muscarinic / drug effects
  • Receptors, Muscarinic / physiology
  • Structure-Activity Relationship


  • Receptors, Muscarinic
  • GTP-Binding Proteins