Vaccination with two different vaccinia recombinant viruses: long-term inhibition of secondary vaccination

Vaccine. 1993;11(11):1154-8. doi: 10.1016/0264-410x(93)90079-d.


The effects of immunity to vaccinia virus on the efficiency of vaccination with a vaccinia recombinant virus were studied. In mice the efficiency and duration of the B-cell response to the recombinant gene product of a second vaccinia recombinant virus were suppressed for more than 9 months, i.e. practically lifelong. Antibody titres against the recombinant gene product were not only lower but also lasted for a shorter time. Thus, immunity to vaccinia virus may influence both the titre and duration of the antibody response induced by a second distinct vaccinia recombinant vaccine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / analysis
  • B-Lymphocytes / immunology
  • Dose-Response Relationship, Drug
  • Immunoglobulin G / immunology
  • Immunoglobulin M / immunology
  • Lymphocytic choriomeningitis virus / immunology
  • Mice
  • Mice, Inbred DBA
  • Time Factors
  • Vaccination*
  • Vaccines, Synthetic / pharmacology*
  • Vaccinia virus / immunology*
  • Vesicular stomatitis Indiana virus / immunology
  • Viral Proteins / immunology
  • Viral Vaccines / pharmacology*


  • Antibodies, Viral
  • Immunoglobulin G
  • Immunoglobulin M
  • Vaccines, Synthetic
  • Viral Proteins
  • Viral Vaccines