Elevation of soluble IL-2 receptor and IL-4, and nonelevation of IFN-gamma in sera from patients with allergic asthma

Ann Allergy. 1993 Nov;71(5):455-8.


To determine whether the predominant in vivo activation of Th1 subset or Th2 subset in peripheral blood occurs in patients with allergic asthma, we measured serum levels of Th1 cell-derived interferon-gamma (IFN-gamma) and Th2 cell-derived interleukin-4 (IL-4). In addition, serum levels of soluble interleukin-2 receptor (sIL-2R) released from activated T cells were measured to determine a potential source of these cytokines. The elevation of serum IL-4 levels and nonelevation of serum IFN-gamma levels were observed in patients with allergic asthma compared with normal control subjects. A significant correlation between serum IL-4 levels and serum sIL-2R levels was observed in these patients. These results suggest that there is allergen-induced in vivo activation of Th2-like cells in peripheral blood of patients with allergic asthma.

MeSH terms

  • Adult
  • Asthma / blood*
  • Female
  • Humans
  • Interferon-gamma / blood*
  • Interleukin-4 / blood*
  • Male
  • Middle Aged
  • Receptors, Interleukin-2 / analysis*
  • Solubility
  • T-Lymphocyte Subsets / chemistry
  • T-Lymphocytes / chemistry
  • T-Lymphocytes / ultrastructure


  • Receptors, Interleukin-2
  • Interleukin-4
  • Interferon-gamma