Parvalbumin-immunoreactive cortical neurons in Creutzfeldt-Jakob disease

Ann Neurol. 1993 Dec;34(6):864-6. doi: 10.1002/ana.410340617.


Massive abnormalities of parvalbumin-immunoreactive cortical neurons were observed in the cerebral biopsy samples of 3 patients with Creutzfeldt-Jakob disease. Immunoreactive cells had reduced and short, often fragmented, dendrites, and large numbers of dendritic varicosities were observed. Since parvalbumin-immunoreactive neurons are the most important inhibitory cells in the cerebral cortex, the damage to these neurons may account, in part, for the impaired cortical function, and may play a role in the appearance of myoclonus and electroencephalographic patterns in patients with Creutzfeldt-Jakob disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cerebral Cortex / pathology*
  • Creutzfeldt-Jakob Syndrome / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neurons / pathology*
  • Parvalbumins / immunology
  • Parvalbumins / metabolism*


  • Parvalbumins