Multiple hamartoma syndrome with osteosarcoma

Arch Pathol Lab Med. 1993 Dec;117(12):1252-4.


Multiple hamartoma syndrome, also known as Cowden's disease, is a rare genodermatosis with characteristic mucocutaneous lesions associated with multiple internal abnormalities. We describe a patient having classic dermatologic manifestations of Cowden's disease and multiple neoplasia including follicular adenocarcinoma of the thyroid gland with lung metastasis, intraductal breast carcinoma within a fibroadenoma, and an osteosarcoma. To our knowledge, this is the first reported case of an osteosarcoma in Cowden's disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Neoplasms / etiology
  • Bone Neoplasms / pathology*
  • Female
  • Hamartoma Syndrome, Multiple / complications
  • Hamartoma Syndrome, Multiple / pathology*
  • Humans
  • Osteosarcoma / etiology
  • Osteosarcoma / pathology*
  • Thyroid Neoplasms / etiology
  • Thyroid Neoplasms / pathology*