The transjugular liver biopsy is a method which allows assessment of hepatic tissue from patients with contraindications against classical percutaneous biopsy. A catheter with a long biopsy needle within is inserted into the jugular vein and then pushed forward through the Vena cava into a hepatic vein in order to carry out the biopsy of the liver. Indications for this examination are biopsies in patients with considerably impaired coagulation or tense ascites. It is possible, if necessary, to measure free and wedged pressure within the liver veins during this examination. On average, in 93% of all examinations enough tissue is yielded to allow for satisfactory judgement of histological changes; the rate of success is little less than that with percutaneous biopsies. However, considering all aspects, this technique gives good results. Lethal complications are rare (0.17%); the total complication rate is about 12%, 0.5-2.7% are severe. Although this method needs more time and technical equipment than percutaneous biopsy, the procedure has to be considered as an important technique for the evaluation of terminal liver disease.