Phototoxic eruptions due to doxycycline--a dose-related phenomenon

Clin Exp Dermatol. 1993 Sep;18(5):425-7. doi: 10.1111/j.1365-2230.1993.tb02242.x.


The tetracycline group of antibiotics still remains the most successful oral treatment for acne. They are relatively free from side-effects apart from the occasional gastrointestinal upset or vaginal candidosis. Rarer side-effects include drug rashes, pigmentation with minocycline and a light-sensitive eruption with doxycycline. The incidence of light-sensitive rashes with doxycycline at a dose of 100 mg daily, is in the order of 3%. Acne does not always respond to conventional regimens of antibiotics and higher dosages may be required. We report a highly significant incidence of light-sensitive eruptions in patients receiving doxycycline at a daily dose of 150 mg or above.

MeSH terms

  • Acne Vulgaris / drug therapy
  • Adolescent
  • Adult
  • Dermatitis, Phototoxic / etiology*
  • Dose-Response Relationship, Drug
  • Doxycycline / administration & dosage
  • Doxycycline / adverse effects*
  • Drug Eruptions / etiology*
  • Humans
  • Middle Aged


  • Doxycycline