Bronchiolitis obliterans organizing pneumonia associated with massive L-tryptophan ingestion

Chest. 1993 Dec;104(6):1924-6. doi: 10.1378/chest.104.6.1924.


A 51-year-old woman developed acute febrile illness with respiratory failure following intake of L-tryptophan. An open lung biopsy specimen established the histopathologic nature of the lung lesion as bronchiolitis obliterans organizing pneumonia (BOOP). There was no evidence of other known causes usually associated with BOOP. Her condition improved with corticosteroid therapy. The entity of BOOP now should be added to the growing list of illnesses associated with the use of L-tryptophan.

Publication types

  • Case Reports

MeSH terms

  • Bronchiolitis Obliterans / chemically induced*
  • Bronchiolitis Obliterans / diagnostic imaging
  • Bronchiolitis Obliterans / pathology
  • Female
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Middle Aged
  • Pneumonia / chemically induced*
  • Pneumonia / diagnostic imaging
  • Pneumonia / pathology
  • Radiography
  • Tryptophan / adverse effects*


  • Tryptophan