Serotonin-5-O-carboxymethyl-glycyl[125I]tyrosinamide labels the 5-HT1D beta receptor subtype in human cortex

Eur J Pharmacol. 1993 Sep 28;242(2):195-8. doi: 10.1016/0014-2999(93)90080-2.


This study, carried out in human cerebral cortical membranes, confirms previous findings in human substantia nigra that serotonin-5-O-carboxymethyl-glycyl[125I]tyrosinamide ([125I]GTI) labels a homogeneous population of recognition sites consistent with a 5-HT1D receptor pharmacology. In addition the results indicate that, under the assay conditions described, [125I]GTI specifically labels the 5-HT1D beta recognition site since ketanserin and ritanserin display a low affinity consistent with their activities at this subtype of the 5-HT1D receptor.

MeSH terms

  • Cerebral Cortex / metabolism*
  • Dipeptides / metabolism*
  • Humans
  • In Vitro Techniques
  • Iodine Radioisotopes
  • Radioligand Assay
  • Receptors, Serotonin / metabolism*
  • Serotonin / analogs & derivatives*
  • Serotonin / metabolism


  • Dipeptides
  • Iodine Radioisotopes
  • Receptors, Serotonin
  • serotonin-O-carboxymethyl-Gly-Tyr
  • Serotonin