Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist"

J Med Chem. 1993 Nov 26;36(24):3975-77. doi: 10.1021/jm00076a028.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cocaine / analogs & derivatives*
  • Cocaine / antagonists & inhibitors*
  • Cocaine / chemical synthesis
  • Cocaine / chemistry
  • Cocaine / metabolism
  • Cocaine / pharmacology
  • Dopamine / metabolism*
  • Mazindol / metabolism
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • methyl 3-benzoyloxy-7-methoxy-8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylate
  • Mazindol
  • Cocaine
  • Dopamine