[Gonadotropes]

Nihon Rinsho. 1993 Oct;51(10):2598-605.
[Article in Japanese]

Abstract

A pulsatile pattern of GnRH release by GnRH pulse generator in the hypothalamus is required for the maintenance of gonadotrope responses, Gn-subunit mRNA production and release of Gn. GnRH causes up-and down-regulation of GnRH receptors and desensitization of Gn-release. Gn-synthesis and release are modulated by gonadal steroid and peptide hormone through the hypothalamus and/or pituitary.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Down-Regulation
  • Estrogens / physiology
  • Female
  • Gonadotropin-Releasing Hormone / metabolism
  • Gonadotropins / biosynthesis*
  • Gonadotropins / genetics
  • Humans
  • Hypothalamus / metabolism
  • Male
  • Pituitary Gland, Anterior / cytology
  • Pituitary Gland, Anterior / metabolism*
  • Progesterone / physiology
  • RNA, Messenger / biosynthesis
  • Rats
  • Receptors, LHRH / metabolism
  • Up-Regulation

Substances

  • Estrogens
  • Gonadotropins
  • RNA, Messenger
  • Receptors, LHRH
  • Gonadotropin-Releasing Hormone
  • Progesterone