[A case of pulmonary lymphangiomyomatosis treated with bilateral oophorectomy and methyl-progesterone-acetate]

Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Sep;31(9):1146-50.
[Article in Japanese]


A case of pulmonary lymphangiomyomatosis is reported. A 37-year-old woman was admitted with hemosputum and dyspnea on exertion. Chest roentgenogram revealed diffuse reticulonodular shadows and arterial hypoxemia was present. Pulmonary function tests showed severe restrictive & obstructive impairment, and pulmonary perfusion scintigraphy with 99mTc-MAA showed non-segmental disproportion. The histological diagnosis of pulmonary lymphangiomyomatosis was made by transbronchial lung biopsy. She underwent bilateral oophorectomy under general anesthesia. However, the arterial hypoxemia advanced gradually, and medroxyprogesterone-acetate (MPA) was commenced (200 mg/day). Her condition remained stable after the description of MPA.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Female
  • Humans
  • Lung Neoplasms / therapy*
  • Lymphangioleiomyomatosis / therapy*
  • Medroxyprogesterone Acetate / administration & dosage*
  • Ovariectomy*


  • Medroxyprogesterone Acetate