Effects of calcium channel entry blockers on cocaine and amphetamine-induced motor activities and toxicities

Life Sci. 1993;53(26):1947-56. doi: 10.1016/0024-3205(93)90016-v.


The effects of calcium channel entry blockers on cocaine and amphetamine-induced behavioral responses were investigated. Cocaine and amphetamine produced dose-dependent increases in locomotor activity and stereotyped behavior with a maximum response at 40 and 1.2 mg/kg, respectively. The 1,4-dihydropyridine nimodipine and the benzothiazepine diltiazem were more effective in inhibiting cocaine (20 mg/kg)-induced responses than amphetamine (0.6 mg/kg)-induced responses. At doses of cocaine and amphetamine that caused seizures and death, nimodipine, nitrendipine and diltiazem did not offer any protection; rather, they potentiated the toxicities produced by these psychomotor stimulants.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amphetamine / antagonists & inhibitors*
  • Amphetamine / pharmacokinetics
  • Amphetamine / toxicity*
  • Animals
  • Calcium Channel Blockers / pharmacokinetics
  • Calcium Channel Blockers / pharmacology*
  • Cocaine / antagonists & inhibitors*
  • Cocaine / pharmacokinetics
  • Cocaine / toxicity*
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Male
  • Motor Activity / drug effects*
  • Rats
  • Rats, Wistar
  • Stereotyped Behavior / drug effects
  • Time Factors


  • Calcium Channel Blockers
  • Amphetamine
  • Cocaine