A morphological biosensor for mammalian cells

Nature. 1993 Dec 9;366(6455):591-2. doi: 10.1038/366591a0.

Abstract

An electrical biosensor is described that can continuously track morphological changes of adherent cells providing quantitative data from both sparse and confluent cultures. The method is capable of detecting vertical motion of cells of the order of 1 nm, much below the resolution of an optical microscope.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma
  • Animals
  • Biosensing Techniques*
  • Cattle
  • Cell Adhesion
  • Cell Movement
  • Cells, Cultured / cytology*
  • Cells, Cultured / physiology*
  • Electrophysiology / instrumentation
  • Electrophysiology / methods
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / physiology
  • Macrophages / cytology
  • Macrophages / physiology
  • Male
  • Mammals
  • Mice
  • Prostatic Neoplasms
  • Rats
  • Tumor Cells, Cultured