Increased anti-Sm antibodies in schizophrenic patients and their families

Prog Neuropsychopharmacol Biol Psychiatry. 1993 Sep;17(5):793-800. doi: 10.1016/0278-5846(93)90061-v.


1. Autoantibodies in the Sm complex have become a useful serologic aid in the diagnosis of systemic lupus erythematosus (SLE) and have rarely been observed in other diseases. 2. A subset of SLE patients have a variety of psychiatric abnormalities, including schizophrenia. 3. The authors have recently observed that schizophrenic patients have a high incidence of autoantibodies suggesting that autoimmune phenomena may play a role in the pathogenesis of this disease. 4. In the present study the authors investigated multicase families with schizophrenia for the presence of anti-Sm antibodies and showed that these autoantibodies are elevated both in patients and in their healthy relatives. 5. An autoimmune process may be involved in the pathology of schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Autoantibodies / analysis*
  • Autoantigens / immunology*
  • Electrophoresis, Polyacrylamide Gel
  • Enzyme-Linked Immunosorbent Assay
  • Family
  • Female
  • Humans
  • Immunoblotting
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • Middle Aged
  • Ribonucleoproteins / immunology*
  • Ribonucleoproteins, Small Nuclear*
  • Schizophrenia / genetics
  • Schizophrenia / immunology*
  • snRNP Core Proteins


  • Autoantibodies
  • Autoantigens
  • Ribonucleoproteins
  • Ribonucleoproteins, Small Nuclear
  • snRNP Core Proteins