Antigen processing and intracellular traffic of antigens and MHC molecules

Curr Opin Cell Biol. 1993 Aug;5(4):596-605. doi: 10.1016/0955-0674(93)90128-d.


Antigen processing leads to binding of antigenic peptides to major histocompatibility complex (MHC) molecules, and these peptide-MHC complexes are recognized by T cells. The class I and class II MHC antigen processing pathways employ different mechanisms and patterns of intracellular transport that allow the two classes to bind and present peptides from different subcellular compartments, determining the source and nature of peptides to be presented.

Publication types

  • Review

MeSH terms

  • Cytosol / immunology
  • Endocytosis / immunology
  • Histocompatibility Antigens Class I / immunology*
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Major Histocompatibility Complex / immunology*
  • Peptides / metabolism
  • Protein Binding


  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Peptides